| ORIGINAL ARTICLE |
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| Year : 2016 | Volume
: 16
| Issue : 1 | Page : 6-9 |
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Cytokines responses to human African trypanosomiasis infection in Abraka, Nigeria
C Isaac1, OPG Nmorsi2, IB Igbinosa1
1 Department of Zoology, Ambrose Alli University, Ekpoma, Nigeria
2 Department of Medical Microbiology and Parasitology, College of Health Sciences, Delta State University, Abraka, Nigeria
Correspondence Address:
C Isaac
Department of Zoology, Ambrose Alli University, Ekpoma
Nigeria
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/1596-4078.189972
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Background: The staging of human African trypanosomiasis (HAT) has been greeted with different benchmarks ranging from white blood cell counts to the use of immune component profiles across regions.
Objective: The aim of this study was to analyze an array of cytokines to identify potential markers that could be used in the staging of HAT in Nigeria.
Methods: Sera and cerebrospinal fluid (CSF) of 35 HAT seropositives from Abraka, Delta State, Nigeria were subjected to cytokines (interleukin-10 [IL-10], tumor necrosis factor-α, IL-1α, IL-7, and IL-13) analysis using enzyme-linked immunosorbent assay. Welch t-test and Tukey analysis of variance were used to analyze the data.
Results: Comparing mean cytokine levels of weakly, moderately, and strongly positives and between as early and late stages results showed significantly depressed CSF levels of IL-1α and IL-7 while IL-10 was significantly elevated in the strongly positives as well as in the late stage.
Conclusion: We strongly suggest that IL-10 could be playing a key role in the immuno-pathology of HAT, thus should be considered a biomarker for the late stage. |
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